Computational Modeling of Signaling Networks
نویسندگان
چکیده
This volume focuses on the computational modeling of cell signaling networks and application these models model-based analysis to systems
منابع مشابه
Computational modeling of mammalian signaling networks.
One of the most exciting developments in signal transduction research has been the proliferation of studies in which a biological discovery was initiated by computational modeling. In this study, we review the major efforts that enable such studies. First, we describe the experimental technologies that are generally used to identify the molecular components and interactions in, and dynamic beha...
متن کاملComputational modeling of dynamic decision making using connectionist networks
In this research connectionist modeling of decision making has been presented. Important areas for decision making in the brain are thalamus, prefrontal cortex and Amygdala. Connectionist modeling with 3 parts representative for these 3 areas is made based the result of Iowa Gambling Task. In many researches Iowa Gambling Task is used to study emotional decision making. In these kind of decisio...
متن کاملModeling of signaling networks.
Biochemical networks, including those containing signaling pathways, display a wide range of regulatory properties. These include the ability to propagate information across different time scales and to function as switches and oscillators. The mechanisms underlying these complex behaviors involve many interacting components and cannot be understood by experiments alone. The development of comp...
متن کاملComputational modeling of neuronal networks
Human brain contains about 10 billion neurons, each of which has about 10~10,000 nerve endings from which neurotransmitters are released in response to incoming spikes, and the released neurotransmitters then bind to receptors located in the postsynaptic neurons. However, individually, neurons are noisy and synaptic release is in general unreliable. But groups of neurons that are arranged in sp...
متن کاملComputational modeling of cytokine signaling in microglia.
Neuroinflammation due to glial activation has been linked to many CNS diseases. We developed a computational model of a microglial cytokine interaction network to study the regulatory mechanisms of microglia-mediated neuroinflammation. We established a literature-based cytokine network, including TNFα, TGFβ, and IL-10, and fitted a mathematical model to published data from LPS-treated microglia...
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ژورنال
عنوان ژورنال: Methods in molecular biology
سال: 2023
ISSN: ['1940-6029', '1064-3745']
DOI: https://doi.org/10.1007/978-1-0716-3008-2